Article

Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer progression

2022-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Tissue stem-progenitor cell frequency has been implicated in tumor risk and progression. Tissue-specific factors linking stem-progenitor cell frequency to cancer risk and progression remain ill defined. Using a genetically engineered mouse model that promotes integrin mechanosignaling with syngeneic manipulations, spheroid models, and patient-derived xenografts we determined that a stiff extrace...

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Literature Corpus work: febc5db1-563e-5848-ba2c-d6a01de838c2
DOI: 10.1101/2022.04.19.487741

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