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Article

Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis

14 Jun 2013

Abstract excerpt

Receptor Activator of NF-kappa B (RANK) pathway controls mammary gland development in mice but its role in mammary stem cell fate remains undefined. We show that constitutive RANK signaling expands luminal and basal mammary compartments including mammary stem and luminal progenitor cell pools and interferes with the generation of CD61+ and Sca1+ luminal cells and Elf5 expression. Impaired mammary cell commitment...

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PMID: 23766243
DOI: 10.1002/stem.1454

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