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Article

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.

Nature medicine - 1 Dec 2008

Eirew Peter, Stingl John, Raouf Afshin, Turashvili Gulisa, Aparicio Samuel, Emerman Joanne T, Eaves Connie J

Abstract excerpt

Previous studies have demonstrated that normal mouse mammary tissue contains a rare subset of mammary stem cells. We now describe a method for detecting an analogous subpopulation in normal human mammary tissue. Dissociated cells are suspended with fibroblasts in collagen gels, which are then implanted under the kidney capsule of hormone-treated immunodeficient mice. After 2-8 weeks, the gels contain bilayered...

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Identifiers

PMID: 19029987
DOI: 10.1038/nm.1791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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