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Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissues

23 Dec 2022

Abstract excerpt

Mechanical forces play a fundamental role in cellular dynamics from the molecular level to the establishment of complex heterogeneity in somatic and stem cells. Here, we highlight the role of cytoskeletal mechanics and extracellular matrix in generating mechanical forces merging into oscillatory synchronized patterns. We discuss how cellular mechanosensing/-transduction can be modulated by mechanical forces to...

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PMID: 36647385
DOI: 10.1016/j.isci.2022.105875

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