Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer.

doi:10.1038/s41467-021-27220-9

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Article

Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer.

Nature communications - 29 Nov 2021

Munne Pauliina M, Martikainen Lahja, Räty Iiris, Bertula Kia, Nonappa, Ruuska Janika, Ala-Hongisto Hanna, Peura Aino, Hollmann Babette, Euro Lilya, Yavuz Kerim, Patrikainen Linda, Salmela Maria, Pokki Juho, Kivento Mikko, Väänänen Juho, Suomi Tomi, Nevalaita Liina, Mutka Minna, Kovanen Panu, Leidenius Marjut, Meretoja Tuomo, Hukkinen Katja, Monni Outi, Pouwels Jeroen, Sahu Biswajyoti, Mattson Johanna, Joensuu Heikki, Heikkilä Päivi, Elo Laura L, Metcalfe Ciara, Junttila Melissa R, Ikkala Olli, Klefström Juha

Abstract excerpt

Breast cancer is now globally the most frequent cancer and leading cause of women's death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα + ) phenotype that is initially responsive to antihormonal therapies, but drug resistance emerges. A major barrier to the understanding of the ERα-pathway biology and therapeutic discoveries is the restricted repertoire of luminal ERα + breast...

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PMID: 34845227
DOI: 10.1038/s41467-021-27220-9
PMCID: PMC8630031

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