Contractile fibroblasts are recruited to the growing mammary epithelium to support branching morphogenesis

Abstract excerpt

Fibroblasts are stromal cells found in connective tissue that are critical for organ development, homeostasis, and disease. Single-cell transcriptomic analyses have revealed a high level of inter- and intra-organ heterogeneity of fibroblasts. However, the functional implications and lineage relations of different fibroblast subtypes remain unexplored, especially in the mammary gland. Here we provide a comprehensiv...

Topics

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• Disease
• Fibroblasts
• Gene Knock-In Techniques
• Organ Specificity
• RNA-Seq
• Single-Cell Analysis
• Stromal Cells
• Transcriptome

Identifiers and source

Literature Corpus work

2dbaf001-0632-568d-a661-99382c6ee28c

DOI

10.1101/2024.06.05.597593