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Article

Integrin-identity shapes and mechanotemporally encodes the fibroblast transcriptome

2026-06-19

Abstract excerpt

<h4>ABSTRACT</h4> Fibroblast transcriptomic states reflect physiological and pathological tissue contexts, yet the upstream determinants that stabilize these states remain poorly defined. Integrins mediate extracellular matrix (ECM) adhesion and biochemical signaling, but whether they encode mechanical constraints into stable transcriptomic programs is unclear. Using engineered mouse fibroblasts, bulk and single-...

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Literature Corpus work
dc2e8b48-cc36-5bf4-bd58-75c7c08433a3
DOI
10.64898/2026.06.17.733008
Open publication

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Integrin-identity shapes and mechanotemporally encodes the fibroblast transcriptomeDOI 10.64898/2026.06.17.733008
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