Article

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction

2025-07-11

Abstract excerpt

Chronic lung injury generates metaplasia which occasionally, but ominously, progresses to squamous dysplasia and squamous lung cancer. To identify mechanisms through which disrupted tissue homeostasis contributes to malignant initiation and progression, we used in vivo and in vitro heterotypic recombinant models of human b ronchial e pithelial c ells (hBECs) and fibroblasts. We demonstrate that injury-associa...

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Literature Corpus work: 1a2d079a-8e39-5ad7-97aa-50169b9cbe2e
DOI: 10.1101/2025.07.11.661192

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