Article
Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.
Oncogene - 10 Dec 2009
Provenzano P P, Inman D R, Eliceiri K W, Keely P J
Abstract excerpt
Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma, yet the associated molecular mechanisms remain largely unknown. Importantly, regions of high breast density are associated with increased stromal collagen and epithelial cell content. We set out to determine whether increased collagen-matrix density, in the absence of stromal cells, was sufficient to promote...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.