Article

CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery

2024-01-30

Abstract excerpt

To address a wide range of genetic diseases, genome editing tools that can achieve targeted delivery of large genes without causing double-stand breaks (DSBs) or requiring DNA templates are necessary. Here, we introduce the CRISPR-Enabled Autonomous Transposable Element (CREATE), a genome editing system that combines the programmability and precision of CRISPR/Cas9 with the RNA-mediated gene insertion capabilities...

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Literature Corpus work: c3271eac-9aae-5bc3-bb6e-f16a15cfe67c
DOI: 10.1101/2024.01.29.577809

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