Article

Jagged-1 <sup>+</sup> Tregs Mediate Lymphatic Remodeling in Tumour-Draining Lymph Nodes

2024-06-12

Abstract excerpt

<h4>ABSTRACT</h4> The tumour-draining lymph nodes (tdLNs) are crucial sites for early immune surveillance of tumours. During tumour development, tdLNs undergo significant stromal remodelling that impacts lymph node (LN) architecture. The reconstruction of tdLNs is dependent on the crosstalk between regulatory T cells (Tregs) and resident stromal cells. The Notch ligand Jagged1 (Jag1), highly expressed in skin Tre...

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Literature Corpus work: fe999743-0c53-5ff3-8ce9-0ecb13113e00
DOI: 10.1101/2024.06.10.598373

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