Article

DLL4-Notch3-WNT5B axis is a novel mediator of bi-directional pro-metastatic crosstalk between melanoma and lymphatic endothelial cells

2023-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Despite strong indications that melanoma interaction with lymphatic vessels actively promotes melanoma progression, the molecular mechanisms are not yet completely understood. To characterize molecular factors of this crosstalk we established human primary lymphatic endothelial cell (LEC) co-cultures with human melanoma cell lines. Here, we show that co-culture with melanoma cells induced transc...

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Literature Corpus work: b011967b-6f64-5c4d-87ac-4fe72099e5c6
DOI: 10.1101/2023.04.21.537773

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