TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

Abstract excerpt

<h4>ABSTRACT</h4> Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune-excluded tumor phenotype. However, the molecular mechanisms that sustain TEC-mediated immunosuppression remain largely elusive. Here, we show that autophagy ablation in TECs boosts antitumor immunity by supporting infiltration and effector function of T cells, thereby restricting melanoma growth. In mel...

Topics

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• Autophagy in Disease and Therapy
• Immune cells in cancer
• Immunotherapy and Immune Responses
• Melanoma and MAPK Pathways
• NF-κB Signaling Pathways

Identifiers and source

Literature Corpus work

888f64c7-dae9-5246-a2d7-9a8420459590

DOI

10.1101/2023.04.21.537799