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SIGLEC1 FACILITATES MACROPHAGE-CD8 <sup>+</sup> T CELL INTERACTIONS AND CORRELATES WITH CANCER IMMUNOTHERAPY RESPONSE

2026-07-15

Abstract excerpt

<h4>ABSTRACT</h4> Antigen-presenting cell (APC) interactions with cytotoxic T cells are critical for anti-tumour immunity and response to immune checkpoint blockade (ICB), yet context-specific regulators in the tumour microenvironment remain not fully defined. Here we identify the lectin receptor SIGLEC1 as a key mediator of macrophage–T cell interactions in human melanoma. In a well-characterized patient cohort,...

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Literature Corpus work
dabc9b02-f10e-5826-82f9-ecc1f4565609
DOI
10.64898/2026.07.09.737484
Open publication

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SIGLEC1 FACILITATES MACROPHAGE-CD8 <sup>+</sup> T CELL INTERACTIONS AND CORRELATES WITH CANCER IMMUNOTHERAPY RESPONSEDOI 10.64898/2026.07.09.737484
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