Article

Lymphatic PD-L1 expression restricts tumor-specific CD8 <sup>+</sup> T cell responses

2020-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Lymph node (LN)-resident lymphatic endothelial cells (LECs) mediate peripheral tolerance by self-antigen presentation on MHC-I and constitutive expression of T cell inhibitory molecules, including PD-L1. Tumor-associated LECs also upregulate PD-L1 but the specific role of lymphatic PD-L1 in tumor immunity is not well understood. We generated a mouse model lacking lymphatic PD-L1 expression and c...

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Literature Corpus work: 0949b5b4-b7f3-54d1-9d25-c672f6d4c3ee
DOI: 10.1101/2020.10.22.350934

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