Article

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

2024-12-05

Abstract excerpt

<h4>Summary</h4> Lymphatic vessels play a crucial role in activating anti-tumor immune surveillance but also contribute to metastasis and systemic tumor progression. Whether distinct lymphatic phenotypes exist that govern the switch between immunity and metastasis remains unclear. Here we reveal that cytotoxic immunity normalizes lymphatic function and uncouples immune and metastatic potential. We find that in mi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 266a9856-9f1e-53eb-8ba6-fc6b3fe7a1d5
DOI: 10.1101/2024.12.02.626426

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanomaDOI 10.1101/2024.12.02.626426Read

Leptomeningeal anti-tumor immunity follows unique signaling principlesSemantic proximity Read

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformationsSemantic proximity Read

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasisSemantic proximity Read

Lymphatic-Preserving Treatment Sequencing with Immune Checkpoint Inhibition Unleashes cDC1-Dependent Antitumor Immunity in HNSCCSemantic proximity Read

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph NodesSemantic proximity Read

Impaired lymphatic function accelerates cancer growth.Semantic proximity Read

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loopSemantic proximity Read

Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanomaSemantic proximity Read

Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursorsSemantic proximity Read

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulationSemantic proximity Read

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodesSemantic proximity Read

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodelingSemantic proximity Read