Article

Interferon lambda 4 impacts broadly on hepatitis C virus diversity

2018-04-20

Abstract excerpt

Type III interferons (IFN-λ) are part of the innate immune response to hepatitis C virus (HCV) infection however the specific role of IFN-λ4 and the nature of the viral adaption to this pressure have not been defined. Here we use paired genome-wide human and viral genetic data in 485 patients infected with HCV genotype 3a to explore the role of IFN-λ4 on HCV evolution during chronic infection. We show that genetic...

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Literature Corpus work: fe84bea8-7aec-5963-ad3e-925afad5201d
DOI: 10.1101/305151

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