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Article

Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden.

Virology - 1 Feb 2015

Lu Yi-Fan, Goldstein David B, Urban Thomas J, Bradrick Shelton S

Abstract excerpt

Genetic variants surrounding the interferon-λ3 (IFNL3) gene are strongly associated with clearance of hepatitis C virus (HCV). A variant (rs368234815 TT/ΔG) upstream of IFNL3 was recently implicated to control expression of a novel gene termed IFNL4. We conducted genetic analysis of rs368234815 in a chronic HCV patient cohort and molecular studies of IFNL4 in primary human hepatocytes (PHHs). Analysis of PHHs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25577150
DOI: 10.1016/j.virol.2014.12.020
PMCID: PMC4494652

Genes

IFNL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden.PMID 25577150Read ↗

Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients.Semantic proximity Read ↗

Interferon lambda 4 expression is suppressed by the host during viral infectionSemantic proximity Read ↗

Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions.Semantic proximity Read ↗

IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes.Semantic proximity Read ↗

IFNL4: Notable variants and associated phenotypes.Semantic proximity Read ↗

IFN-λ4: the paradoxical new member of the interferon lambda family.Semantic proximity Read ↗

Interferon-λ4 (IFNL4) Transcript Expression in Human Liver Tissue SamplesSemantic proximity Read ↗

Host - hepatitis C viral interactions: The role of genetics.Semantic proximity Read ↗

Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections.Semantic proximity Read ↗

Interferon lambdas: the next cytokine storm.Semantic proximity Read ↗

Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients.Semantic proximity Read ↗

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.Semantic proximity Read ↗

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