Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients.

doi:10.1093/infdis/jix593

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Article

Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients.

The Journal of infectious diseases - 30 Jan 2018

Rosenberg Brad R, Freije Catherine A, Imanaka Naoko, Chen Spencer T, Eitson Jennifer L, Caron Rachel, Uhl Skyler A, Zeremski Marija, Talal Andrew, Jacobson Ira M, Rice Charles M, Schoggins John W

Abstract excerpt

Polymorphisms at IFNL4 strongly influence spontaneous resolution and interferon therapeutic response in hepatitis C virus (HCV) infection. In chronic HCV, unfavorable alleles are associated with elevated interferon (IFN)-stimulated gene (ISG) expression in the liver, but extrahepatic effects are less well characterized. We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815)...

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Identifiers

PMID: 29165633
DOI: 10.1093/infdis/jix593
PMCID: PMC5853921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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