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Article

An interferon lambda 4-associated variant in the hepatitis C virus RNA polymerase affects viral replication in infected cells.

The Journal of general virology - 1 Feb 2021

Bamford Connor G G, McLauchlan John

Abstract excerpt

Host IFNL4 haplotype status contributes to the development of chronic hepatitis C virus (HCV) infection in individuals who are acutely infected with the virus. In silico studies revealed that specific amino acid variants at multiple sites on the HCV polyprotein correlate with functional single-nucleotide polymorphisms (SNPs) in the IFNL4 locus. Thus, SNPs at the IFNL4 locus may select variants that influence...

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Share to DNA-Directed RNA Polymerases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 32897180
DOI: 10.1099/jgv.0.001495
PMCID: PMC8116938

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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