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Article

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

3 Sept 2019

Abstract excerpt

Hepatitis C virus (HCV) is a highly variable pathogen that frequently establishes chronic infection. This genetic variability is affected by the adaptive immune response but the contribution of other host factors is unclear. Here, we examined the role played by interferon lambda-4 (IFN-λ4) on HCV diversity; IFN-λ4 plays a crucial role in spontaneous clearance or establishment of chronicity following acute...

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PMID: 31478835
DOI: 10.7554/elife.42463

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