Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.

doi:10.1038/ng.3835

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Article

Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus.

Nature genetics - 1 May 2017

Ansari M Azim, Pedergnana Vincent, L C Ip Camilla, Magri Andrea, Von Delft Annette, Bonsall David, Chaturvedi Nimisha, Bartha Istvan, Smith David, Nicholson George, McVean Gilean, Trebes Amy, Piazza Paolo, Fellay Jacques, Cooke Graham, Foster Graham R, Hudson Emma, McLauchlan John, Simmonds Peter, Bowden Rory, Klenerman Paul, Barnes Eleanor, Spencer Chris C A

Abstract excerpt

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. Here we use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals who were chronically infected with HCV, predominantly genotype 3. We show that both alleles of genes encoding human leukocyte antigen molecules...

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Identifiers

PMID: 28394351
DOI: 10.1038/ng.3835
PMCID: PMC5873514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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