Article

Conserved induction of distinct antiviral signalling kinetics by primate interferon lambda 4 proteins

2021-09-16

Abstract excerpt

Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver and gastrointestinal tract. Humans have four IFNλs (1-4) where IFNλ1-3 show ∼80-95% homology and IFNλ4 is the most divergent displaying only ∼30% sequence identity. Variants in IFNλ4 in humans are associated with the outcome of infection, such as with hepati...

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Literature Corpus work: 307b42ee-9950-50d6-bb50-ba6b82bde599
DOI: 10.1101/2021.09.15.460494

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