Article
Impact of virus subtype and host IFNL4 genotype on large-scale RNA structure formation in the genome of hepatitis C virus.
RNA (New York, N.Y.) - 1 Nov 2020
Simmonds Peter, Cuypers Lize, Irving Will L, McLauchlan John, Cooke Graham S, Barnes Ellie, Ansari M Azim
Abstract excerpt
Mechanisms underlying the ability of hepatitis C virus (HCV) to establish persistent infections and induce progressive liver disease remain poorly understood. HCV is one of several positive-stranded RNA viruses capable of establishing persistence in their immunocompetent vertebrate hosts, an attribute previously associated with formation of large-scale RNA structure in their genomic RNA. We developed novel...
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