Article

Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced bactericidal activity

2022-11-04

Abstract excerpt

<h4>SUMMARY</h4> Hematopoietic stem and progenitor cells (HSPCs) respond to infection by proliferating and generating in-demand neutrophils through a process called emergency granulopoiesis (EG). Recently, infection-induced changes in HPSCs have also been shown to underpin the longevity of trained immunity, where they generate innate immune cells with enhanced responses to subsequent microbial threats. Using larv...

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Literature Corpus work: fe7e629c-9834-589a-8de4-b8277c81eda4
DOI: 10.1101/2022.11.03.515114

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