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Hematopoietic stem and progenitor cells as a reservoir for trained immunity

21 Aug 2025

Abstract excerpt

Human and murine studies reveal that innate immune cells are able to mount enhanced responses to pathogens after primary inflammatory exposure. Innate immune memory has been shown to last for months to years, longer than the lifespan of most innate immune cells. Indeed, long-lived hematopoietic stem and progenitor cells (HSPCs) serve as a cellular reservoir for innate immune memory. In this review, we summarize...

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PMID: 40905954
DOI: 10.7554/elife.106610

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