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Random barcode transposon-site sequencing in <i>Mycobacterium tuberculosis</i> reveals the functions of uncharacterized genes

2025-11-13

Abstract excerpt

Mycobacterium tuberculosis (Mtb) is a human bacterial pathogen that establishes chronic infection in the lung. Although the genome of Mtb was sequenced nearly 25 years ago, the genetic basis of Mtb’s success as a human pathogen remains to be fully elucidated. Large-scale genetic approaches to understanding gene function are hindered by the limited throughput of traditional transposon sequencing strategies used in...

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Literature Corpus work
fe60fa3b-0137-5e12-af42-ed6260149794
DOI
10.1101/2025.11.13.688195
Open publication

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Random barcode transposon-site sequencing in <i>Mycobacterium tuberculosis</i> reveals the functions of uncharacterized genesDOI 10.1101/2025.11.13.688195
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