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Temporal genome-wide fitness analysis of <i>Mycobacterium marinum</i> during infection reveals genetic requirement for virulence and survival in amoebae and microglial cells

2023-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis remains the most pervasive infectious disease and the recent emergence of multiple or even fully drug-resistant strains increases the risk and emphasizes the need for more efficient and better drug treatments. A key feature of mycobacteria pathogenesis is the metabolic switch during infection and expression of virulence genes is often adapted to specific infection conditions. This s...

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Literature Corpus work
ed915970-9375-55ef-97e9-46b732c8c502
DOI
10.1101/2023.03.22.533734
Open publication

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Temporal genome-wide fitness analysis of <i>Mycobacterium marinum</i> during infection reveals genetic requirement for virulence and survival in amoebae and microglial cellsDOI 10.1101/2023.03.22.533734
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