Article
Comprehensive analysis of iron utilization by Mycobacterium tuberculosis.
PLoS pathogens - 1 Feb 2020
Zhang Lei, Hendrickson R Curtis, Meikle Virginia, Lefkowitz Elliot J, Ioerger Thomas R, Niederweis Michael
Abstract excerpt
Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis (Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes siderophores, small molecules with high affinity for iron, and takes up iron-loaded mycobactins (MBT) and carboxymycobactins (cMBT), from the environment. Mtb is also capable of utilizing heme and hemoglobin which contain more than 70% of...
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