Article
High-throughput characterization of Mycobacterium tuberculosis gene function across diverse conditions.
PLoS biology - 1 Apr 2026
Dinshaw Kayla M, Lien Katie A, Knight Matthew, Ouonkap Sorel V Yimga, Liu Hualan, Savage David F, Carlson Hans K, Deutschbauer Adam M, Stanley Sarah A
Abstract excerpt
Mycobacterium tuberculosis (Mtb) is a human bacterial pathogen that establishes chronic infection in the lung. Although the genome of Mtb was sequenced nearly 25 years ago, the genetic basis of Mtb's success as a human pathogen remains to be fully elucidated. Large-scale mutation-based genetic approaches to understanding gene function are hindered by the limited throughput of traditional transposon sequencing...
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