Back to search

Article

High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivity

2021-07-01

Abstract excerpt

Mycobacterium abscessus ( Mab ) is a rapidly growing non-tuberculous mycobacterium (NTM) that causes a wide range of infections. Treatment of Mab infections is difficult because the bacterium is intrinsically resistant to many classes of antibiotics. Developing new and effective treatments against Mab requires a better understanding of the unique vulnerabilities that can be targeted for future drug development....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3de94a8c-62d1-5784-8f6a-3e6986fe6539
DOI
10.1101/2021.07.01.450732
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivityDOI 10.1101/2021.07.01.450732
Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity
Random barcode transposon-site sequencing in <i>Mycobacterium tuberculosis</i> reveals the functions of uncharacterized genesSemantic proximity
Peptidoglycan synthesis in <i>Mycobacterium tuberculosis</i> is organized into networks with varying drug susceptibilitySemantic proximity
Genome-Wide Essentiality Analysis of Mycobacterium abscessus by Saturated Transposon Mutagenesis and Deep SequencingSemantic proximity
Glby, is a PBP with β-lactamase activity and is required for <i>in vivo</i> viability of <i>M. abscessus</i>Semantic proximity
The phenotypic landscape of the mycobacterial cellSemantic proximity
High-throughput characterization of Mycobacterium tuberculosis gene function across diverse conditions.Semantic proximity
Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strains.Semantic proximity
Mycobacterium abscessus Mutants with a Compromised Functional Link between the Type VII ESX-3 System and an Iron Uptake Mechanism Reliant on an Unusual Mycobactin SiderophoreSemantic proximity
Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strainsSemantic proximity
Lipid metabolic pathways determine phage infectivity in <i>Mycobacterium abscessus</i>Semantic proximity
Identifying essential genes in Mycobacterium tuberculosis by global phenotypic profiling.Semantic proximity
Select a neighboring publication to make it the new centre.