Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease

30 Nov 2022

Abstract excerpt

Abstract Introduction The inositol polyphosphate‐5‐phosphatase D ( INPP5D ) gene encodes a dual‐specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic Alzheimer's disease (LOAD). Methods To assess the consequences of inducible Inpp5d knockdown in microglia of APP KM670/671NL /PSEN1 Δexon9...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36448627
DOI: 10.1002/alz.12821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's diseasePMID 36448627Read ↗

INPP5D limits plaque formation and glial reactivity in the APP/PS1 mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

INPP5D Expression is Associated with Risk for Alzheimer’s Disease and Induced by Plaque-Associated MicrogliaSemantic proximity Read ↗

<i>INPP5D</i> expression is associated with risk for Alzheimer’s disease and induced by plaque-associated microgliaSemantic proximity Read ↗

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse modelSemantic proximity Read ↗

INPP5D/SHIP1 regulates inflammasome activation in human microgliaSemantic proximity Read ↗

Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology.Semantic proximity Read ↗

INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microgliaSemantic proximity Read ↗

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microgliaSemantic proximity Read ↗

Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer's risk gene mutation.Semantic proximity Read ↗

The SHIP1-inflammatory-lipid axis in Alzheimer's disease: from genetic risk to spatiotemporal mechanistic insights.Semantic proximity Read ↗

Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer’s Knock-in Mice Require Cellular Prion ProteinSemantic proximity Read ↗

A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.