Article

INPP5D Expression is Associated with Risk for Alzheimer’s Disease and Induced by Plaque-Associated Microglia

2020-09-08

Abstract excerpt

<h4>Background: </h4> Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide association studies recently highlighted a prominent role for microglia in late-onset AD (LOAD). Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1, is selectively expressed in brain microg...

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Literature Corpus work: 15d7aab5-b9ba-5fc7-be1c-7ad5b6451f31
DOI: 10.21203/rs.3.rs-69967/v1

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