Article

<i>INPP5D</i> expression is associated with risk for Alzheimer’s disease and induced by plaque-associated microglia

2020-08-31

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide association studies recently highlighted a prominent role for microglia in late-onset AD (LOAD). Specifically, inositol polyphosphate-5-phosphatase ( INPP5D ), also known as SHIP1, is selectively expressed in brain micr...

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Literature Corpus work: bbd5e787-1af6-51b9-ab84-fd8b8b7e6cf1
DOI: 10.1101/2020.08.31.276444

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