Article

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

2023-05-04

Abstract excerpt

<h4>ABSTRACT</h4> 53BP1 is a well-established DNA damage repair factor recently shown to regulate gene expression and critically influence tumor suppression and neural development. For gene regulation, how 53BP1 is regulated remains unclear. Here, we showed that 53BP1-serine 25 phosphorylation by ATM is required for neural progenitor cell proliferation and neuronal differentiation in cortical organoids. 53BP1-ser...

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Literature Corpus work: fe270e0d-254f-5275-9b27-b2a4f13c746a
DOI: 10.1101/2023.05.04.539457

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