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Article

The ATM signaling network in development and disease

1 Jan 2013

Abstract excerpt

The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the appropriate cellular programs to maintain genome integrity. This includes the coordination of cell cycle checkpoints, transcription, translation, DNA repair, metabolism, and cell fate decisions, such as apoptosis or senescence (Jackson and Bartek, 2009). DNA double-strand breaks (DSBs) represent one of the most cytotoxic DNA lesions...

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PMID: 23532176
DOI: 10.3389/fgene.2013.00037

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