Article

p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2

2021-07-06

Abstract excerpt

<h4>Summary</h4> Proper gene regulation is critical for both neuronal development and maintenance as the brain matures. We previously demonstrated that Akirin2, an essential nuclear protein that interacts with transcription factors and chromatin remodeling complexes, is required for the embryonic formation of the cerebral cortex. Here we show that Akirin2 plays a mechanistically distinct role in maintaining healt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 295d9703-6397-5dd7-88c6-d9f482771358
DOI: 10.1101/2021.07.05.451155

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2DOI 10.1101/2021.07.05.451155Read

Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromesSemantic proximity Read

Identification of TIA1 mRNA targets during human neuronal developmentSemantic proximity Read

Cell type-specific dysregulation of gene expression due to <i>Chd8</i> haploinsufficiency during mouse cortical developmentSemantic proximity Read

hnRNPs: roles in neurodevelopment and implication for brain disordersSemantic proximity Read

<i>De novo MAP2K4</i> variants cause a novel neurodevelopmental syndrome with impaired JNK signaling in iPSC-derived neuronsSemantic proximity Read

Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilitiesSemantic proximity Read

Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex developmentSemantic proximity Read

Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21Semantic proximity Read

Reduction of HDAC2 expression in human induced pluripotent stem cell derived neurons improves neuronal maturation, mitochondrial dynamics and cellular neurodegenerative disease phenotypesSemantic proximity Read

Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain.Semantic proximity Read

Dynamic proteomic and phosphoproteomic atlas of corticostriatal axon neurodevelopmentSemantic proximity Read

Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndromeSemantic proximity Read