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A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain Cancer

11 Sept 2020

Abstract excerpt

p53 is one of the most intensively studied tumor suppressors. It transcriptionally regulates a broad range of genes to modulate a series of cellular events, including DNA damage repair, cell cycle arrest, senescence, apoptosis, ferroptosis, autophagy, and metabolic remodeling, which are fundamental for both development and cancer. This review discusses the role of p53 in brain development, neural stem cell...

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PMID: 32932978
DOI: 10.3390/biology9090285

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