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Retinoblastoma binding protein 4 maintains cycling neural stem cells and prevents DNA damage and Tp53-dependent apoptosis in <i>rb1</i> mutant neural progenitors

2018-09-25

Abstract excerpt

Retinoblastoma-binding protein 4 (Rbbp4) is a WDR adaptor protein for multiple chromatin remodelers implicated in human oncogenesis. Here we show Rbbp4 is overexpressed in zebrafish rb1 -embryonal brain tumors and is upregulated across the spectrum of human embryonal and glial brain cancers. We demonstrate in vivo Rbbp4 is essential for zebrafish neurogenesis and has distinct roles in neural stem and progenitor...

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Literature Corpus work
cdd889b6-2ac0-56cf-b30a-fa84111861c7
DOI
10.1101/427344
Open publication

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