Article

<i>BRCA1</i> is a molecular correlate of cell proliferation in human brain development and in Group 3 and 4 medulloblastoma

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> The role of the BRCA1-mediated DNA damage repair pathway in regulating human brain development remains unknown, although it has been studied in mouse development. We report evidence for breast cancer type 1 susceptibility protein (BRCA1) being a molecular correlate of proliferation in human neural progenitor cells and in medulloblastoma (MB), a malignant pediatric hindbrain cancer whose cells re...

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Identifiers and source

Literature Corpus work: 8328eeca-2767-524d-9f72-7cae87c7b812
DOI: 10.1101/2025.04.03.646803

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