Article

A human-specific, concerted repression of microcephaly genes contributes to radiation-induced growth defects in forebrain organoids

2024-06-27

Abstract excerpt

<h4> Abstract </h4> Prenatal radiation-induced DNA damage poses a significant threat to normal brain development, resulting in microcephaly which primarily affects the cerebral cortex. It is unclear which molecular mechanisms are at the basis of this defect in humans as the few mechanistic studies performed so far were done in animals. Here, we leveraged human embryonic stem cell- derived forebrain organoids as...

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Literature Corpus work: 8ad03293-ad82-52f6-aea2-44c28fc347ad
DOI: 10.1101/2024.06.27.600564

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