Article

The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variant

2021-11-10

Abstract excerpt

<h4>SUMMARY</h4> Variants of concern (VOCs) of severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) threaten the global response to the COVID-19 pandemic. The alpha (B.1.1.7) variant appeared in the UK became dominant in Europe and North America in early 2021. The Spike glycoprotein of alpha has acquired a number mutations including the P681H mutation in the polybasic cleavage site that has been sugg...

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Literature Corpus work: fe0d4118-fdad-52f4-bc3e-6676794300b8
DOI: 10.1101/2021.11.09.467693

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