Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance.

Journal of virology - 14 Dec 2022

Lista Maria Jose, Winstone Helena, Wilson Harry D, Dyer Adam, Pickering Suzanne, Galao Rui Pedro, De Lorenzo Giuditta, Cowton Vanessa M, Furnon Wilhelm, Suarez Nicolas, Orton Richard, Palmarini Massimo, Patel Arvind H, Snell Luke, Nebbia Gaia, Swanson Chad, Neil Stuart J D

Abstract excerpt

The appearance of new dominant variants of concern (VOC) of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) threatens the global response to the coronavirus disease 2019 (COVID-19) pandemic. Of these, the alpha variant (also known as B.1.1.7), which appeared initially in the United Kingdom, became the dominant variant in much of Europe and North America in the first half of 2021. The spike (S)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to COVID-19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Type I

Share to Membrane Proteins

Share to RNA-Binding Proteins

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 36350154
DOI: 10.1128/jvi.01250-22
PMCID: PMC9749455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance.PMID 36350154Read ↗

The P681H mutation in the Spike glycoprotein escapes IFITM restriction and is necessary for type I interferon resistance in the SARS-CoV-2 alpha variantSemantic proximity Read ↗

The P681H mutation in the Spike glycoprotein confers Type I interferon resistance in the SARS-CoV-2 alpha (B.1.1.7) variantSemantic proximity Read ↗

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.Semantic proximity Read ↗

SARS-COV-2 γ variant acquires spike P681H or P681R for improved viral fitnessSemantic proximity Read ↗

Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spikeSemantic proximity Read ↗

Evolution of enhanced innate immune evasion by SARS-CoV-2Semantic proximity Read ↗

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.Semantic proximity Read ↗

In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamstersSemantic proximity Read ↗

Global Spread of SARS-CoV-2 Subtype with Spike Protein Mutation D614G is Shaped by Human Genomic Variations that Regulate Expression of <i>TMPRSS2</i> and <i>MX1</i> GenesSemantic proximity Read ↗

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variantSemantic proximity Read ↗

Screening for the <i>alpha</i> variant of SARS-CoV-2 (B.1.1.7) the impact of this variant on circulating biomarkers in hospitalised patientsSemantic proximity Read ↗

The N501Y spike substitution enhances SARS-CoV-2 infection and transmission.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.