Article

Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike

2021-04-08

Abstract excerpt

<h4>Summary</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the COVID-19 pandemic. SARS-CoV-2 B.1.1.7 (Alpha), a WHO variant of concern (VOC) first identified in the UK in late 2020, contains several mutations including P681H in the spike S1/S2 cleavage site, which is predicted to increase cleavage by furin, potentially impacting the viral cell entry. Here, we studied the ro...

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Literature Corpus work: 842ebb5f-3505-5a9e-badb-9617c77d0b8e
DOI: 10.1101/2021.04.06.438731

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