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Article

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

Cell reports - 17 May 2022

Liu Yang, Liu Jianying, Johnson Bryan A, Xia Hongjie, Ku Zhiqiang, Schindewolf Craig, Widen Steven G, An Zhiqiang, Weaver Scott C, Menachery Vineet D, Xie Xuping, Shi Pei-Yong

Abstract excerpt

We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the coronavirus disease 2019 (COVID-19) pandemic. Delta SARS-CoV-2 efficiently outcompetes the Alpha variant in human lung epithelial cells and primary human airway tissues. The Delta spike mutation P681R is located at a furin cleavage site that...

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Identifiers

PMID: 35550680
DOI: 10.1016/j.celrep.2022.110829
PMCID: PMC9050581

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