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Article

Interferon resistance of emerging SARS-CoV-2 variants

22 Jul 2022

Abstract excerpt

The emergence of SARS-CoV-2 variants with enhanced transmissibility, pathogenesis, and resistance to vaccines presents urgent challenges for curbing the COVID-19 pandemic. While Spike mutations that enhance virus infectivity or neutralizing antibody evasion may drive the emergence of these novel variants, studies documenting a critical role for interferon responses in the early control of SARS-CoV-2 infection,...

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PMID: 35867811
DOI: 10.1073/pnas.2203760119

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