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Article

Evolution of enhanced innate immune evasion by SARS-CoV-2

23 Dec 2021

Abstract excerpt

Abstract The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission 1,2 . Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of spike are likely to contribute to adaptation. Here, using unbiased abundance proteomics, phosphoproteomics, RNA sequencing and viral replication assays,...

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PMID: 34942634
DOI: 10.1038/s41586-021-04352-y

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