Article
Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.
Cell - 5 Mar 2020
Singh Mandeep, Jackson Katherine J L, Wang Jing J, Schofield Peter, Field Matt A, Koppstein David, Peters Timothy J, Burnett Deborah L, Rizzetto Simone, Nevoltris Damien, Masle-Farquhar Etienne, Faulks Megan L, Russell Amanda, Gokal Divya, Hanioka Asami, Horikawa Keisuke, Colella Alexander D, Chataway Timothy K, Blackburn James, Mercer Tim R, Langley David B, Goodall D Margaret, Jefferis Roy, Gangadharan Komala Muralikrishna, Kelleher Anthony D, Suan Dan, Rischmueller Maureen, Christ Daniel, Brink Robert, Luciani Fabio, Gordon Tom P, Goodnow Christopher C, Reed Joanne H
Abstract excerpt
Pathogenic autoantibodies arise in many autoimmune diseases, but it is not understood how the cells making them evade immune checkpoints. Here, single-cell multi-omics analysis demonstrates a shared mechanism with lymphoid malignancy in the formation of public rheumatoid factor autoantibodies responsible for mixed cryoglobulinemic vasculitis. By combining single-cell DNA and RNA sequencing with serum antibody...
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