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Article

Structural diversity of B-cell receptor repertoires along the B-cell differentiation axis in humans and mice

18 Feb 2020

Abstract excerpt

Most current analysis tools for antibody next-generation sequencing data work with primary sequence descriptors, leaving accompanying structural information unharnessed. We have used novel rapid methods to structurally characterize the complementary-determining regions (CDRs) of more than 180 million human and mouse B-cell receptor (BCR) repertoire sequences. These structurally annotated CDRs provide...

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PMID: 32069281
DOI: 10.1371/journal.pcbi.1007636

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