Article

Somatic Genome Diversification and Clonal Evolution of Pathogenic B Cells in Systemic Autoimmunity

2026-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Systemic autoimmune rheumatic diseases are characterized by persistent immune activation and clinical heterogeneity, yet the molecular processes sustaining and diversifying pathogenic immune states remain incompletely understood. Here, we investigate somatic genome diversification as a potential driver of immune variation and disease progression. Using Systemic Lupus Erythematosus as a model dis...

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Literature Corpus work: ca8f184e-70bb-5cbd-b639-3f0898f16117
DOI: 10.64898/2026.06.08.730997

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